SPCG® Technology and Clinical Efficacy

Selkeys maillage protecteur

Notre technologie repose sur une approche de reproduction des mécanismes biologiques afin de renouveler, réactiver et protéger les processus cellulaires de la peau. Chaque formule correspond à une synergie d'ingrédients encapsulés dans un maillage innovant qui maximise la pénétration et l'efficacité des actifs. Nos sérums sont physio-mimétiques. Chacun s’adapte aux besoins physiologiques de chaque type de peau. Les sérums interagissent avec votre peau, copient ses signaux naturels et modulent leurs effets en fonction de son état.

Focus 3 sérums
  • Water capture

    Process of capturing moisture from the environment and transferring it to the skin. This mechanism deeply hydrates the lipid barrier that limits transepidermal water loss (TEWL), by inserting itself into the spaces between lipids.

  • Catalysis of assets

    Process of amplifying the penetration of active ingredients. By optimizing absorption, the effectiveness of the formulas is multiplied. Gradient that promotes the migration of soluble substances to the deep layers of the skin, supporting skin regeneration mechanisms.

  • Preserving the microbiome

    Skin microbiome balancing process. Restoration of natural hydration mechanisms, underlying the preservation of elasticity and firmness. Antimicrobial action.

  • Intercellular cohesion

    Improved cohesion of skin cells, called corneocytes. These cells are arranged in a "bricks and cement" model, where the "bricks" are the corneocytes and the "cement" is the intercellular lipids that hold them together. Increased plasticity of corneocytes + Strengthening of intercellular lipids.

  • Anti-OX

    Anti-oxidation that protects the skin against free radicals, the main factors of premature skin aging. By neutralizing these molecules, helps preserve the skin's radiance and youthfulness while supporting natural cellular repair processes.

  • Super Activity Boost

    Temporary increase in the permeability of the stratum corneum to promote the passage of active ingredients through the epidermis. Opening of the space between cells, facilitating the diffusion of water-soluble active ingredients: improvement of bioavailability, i.e. the ability of active ingredients to reach the cells where they exert their beneficial effects.

Sérums aux extraits végétaux

Sans polluants, sans pesticides, sans phénoxyéthanol, sans allergènes, sans disodium EDTA, sans PEGs, sans actifs synthétiques. Indice de naturalité très élevé, jusqu'à 99%, pour une tolérance maximale éliminant les risques de sensibilisation et d'irritation cutanée. 100% tolérance. 0% Sensibilisation.

In vivo tests

femme applique sérum

A2 Anti-Aging: Primos 3D Lite Scientific Study

Measurements were taken before application (t0) and after 28 days on volunteers aged 32 to 63: length, depth, number, volume of wrinkles and total wrinkled surface. To challenge the serum, only 2 drops per quadrant of the face were applied. Effect on wrinkle length noted on 100% of volunteers (average of -11%). Effect on wrinkle depth noted on 67% with an average of -18%. Number of wrinkles reduced in 100% of participants (on average by 12%); volume reduced by 6% and their area by 10%.

Selkeys efficacité maximale

Anti-aging mode of action

Increases the Ki-67 marker (keratinocyte proliferation): stimulation of cell regeneration. Restructured dermo-epidermal junction, increasing density and volume. Better bonding of the dermis to the epidermis; maintenance of elastic fibers thanks to the increase of 2 glycoproteins. Mimics hygroscopic substances to ensure the plasticity of the horny layer.

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A2 Anti-Aging Serum in detail

The active ingredients in our serum are selected from among the best in the world and all made in France.

  • The first is an anionic polysaccharide obtained by fermentation of non-GMO plant substrates. This active ingredient is approved by ECOCERT GREENLIFE, compliant with the COSMOS and NATRUE standards. It is a neurocosmetic active ingredient (inhibitor of neurogenic inflammation: -25% release of Substance P induced by lactic acid) which reduces tingling sensations, which stimulates youth proteins by +475% and epidermal renewal by +76%. An ex vivo study on incubated explants shows that the active ingredient modulates various reactions and syntheses in the skin such as that of sirtuin-1, loricrin (+76%) and involucrin (+51%) for a restructuring anti-aging effect.
  • The second is a natural alternative to synthetic fillers and tensing polymers. Eco-design and sustainable sourcing for these mucilages rich in sugar, xylose and organic acids from the pulp of the Baobab fruit (organic), also called the "pharmacist tree". In vivo tests show -41% of furrows in the micro-relief of the skin and -24% of wrinkled surface at the level of the crow's feet. This active ingredient is approved by ECOCERT GREENLIFE, compliant with the COSMOS Standard.
  • The third active ingredient rejuvenates the skin by regenerating it more, faster and better, from the basal cells to the surface of the stratum corneum. Composed of ecdysterone (a phytosterol) from a tropical fern, the active ingredient accelerates the establishment of the dermo-epidermal junction and its stabilization. The cohesion between the dermis and the epidermis is reinforced: the skin is firmer and more elastic. In vitro tests have shown the stimulation of cell regeneration (the Ki-67 marker of the proliferation of keratinocytes in the basal layer is 3.3 times more important; the involucrine marking is 5.3 times more intense). +22% collagen in the skin in 35 days. +12% Laminin-5, a glycoprotein involved in the binding of molecules forming the skin matrix. +20% Fibrillin, a glycoprotein essential for the formation of elastic fibers. 3.5 times more skin firmness after 60 days of use.

E3 anti-stain: Antera 3D® scientific study

Defining the direct influence of the serum on the skin tone lightening properties (melanin content reduction) using Antera 3D®. The test was carried out using a special measuring device manufactured by Miravex Limited. Measurements were taken before application (t0) and after 28 days of use on volunteers aged 29 to 69 years. To challenge the serum, only 2 drops per quadrant of the face were applied. An effect was observed on 100% of the volunteers, with a reduction in melanin content of 5%.

Selkeys éclaircit le teint

Anti-stain mode of action

Significant inhibition of the transfer of melanosomes to keratinocytes (reduction of pigmentation). Lightening effect with daily use for 3 months. Inhibition of tyrosinase which prevents the synthesis of melanin.

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E3 Lightening Serum in detail

The active ingredients in our serum are selected from among the best in the world and all made in France.

  • The first is an active ingredient from the Vitamin B group, which has demonstrated its lightening activity in numerous in vitro and in vivo tests with published data (Hakozaki et al, Br. J. Dermatol. 147:20-31 (2002); Greatens et al., Exp. Dermatol. 2005, 14:498-508; Bissett et al, Dermatol. Surg. 2005,31:860–865; Navarrete-Solís et al, Dermatology Research and Practice, Vol 2011).
  • The second is a natural arbutin (hydroquinone glucoside) obtained by extraction without solvents or chemicals. The active ingredient inhibits by 95% tyrosinase, this enzyme of the oxidase category, catalyzing the oxidation of tyrosine into dihydroxyphenylalanine, DOPAquinone and melanins, responsible for all pigment spots. See Maeda, K., & Fukuda, M. (1996). Arbutin: mechanism of its depigmenting action in human melanocyte culture. Journal of Pharmacology and Experimental Therapeutics , 276 (2), 765-769 ; Palumbo, A., d'Ischia, M., Misuraca, G., & Prota, G. (1991). Mechanism of inhibition of melanogenesis by hydroquinone. Biochimica et Biophysica Acta (BBA)-General Subjects , 1073 (1), 85-90.